研究成果

技术标准引领

序号

标准名称

标准编号

标准详情(全国团体标准信息平台)

1

保健食品润肠通便功能的斑马鱼检测方法

T/ZHCA 501-2020

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2

保健食品抗氧化功能的斑马鱼检测方法

T/ZHCA 502-2020

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3

保健食品功能评价 斑马鱼试验规程

T/CHC2003 -2022

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4

化妆品美白功效测试 斑马鱼胚胎黑色素抑制功效测试方法

T/ZHCA 012-2021

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5

化妆品抗皱功效评价 斑马鱼幼鱼尾鳍皱缩抑制率法

T/ZHCA 014-2022

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6

化妆品紧致功效评价 斑马鱼幼鱼弹性蛋白基因相对表达量法

T/ZHCA 015-2022

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7

化妆品舒缓功效评价 斑马鱼幼鱼中性粒细胞抑制率法

T/ZHCA 016-2022

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8

禽肉的斑马鱼胚胎生物效应测试方法

T/CMATB11001-2021

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9

GB/T 39649-2020 实验动物 实验鱼质量控制

GB/T 39649-2020

2022年

10

降血脂食品斑马鱼检测技术团体标准

制订中

2022年

11

斑马鱼用于中药生物效应评价技术指南与团体标准

制订中

2022年

12

食用农产品营养品质评价 斑马鱼卵法

已过评审

2022年

 

部分技术专利

序号

专利名称

专利号

申请日期

1

一种评价药物预防病毒性肺炎的方法

ZL 202010901213.7

2020.08.31

2

一种检测保健食品缓解焦虑功效的方法

ZL 202010885827.0

2020.08.28

3

一种适用于评价多种保健食品改善睡眠功效的方法

ZL 202010783803.4

2020.08.06

4

一种用斑马鱼评价肉制品安全性的方法

ZL 202010257281.4

2020.04.03

5

一种用斑马鱼评价乳制品睡眠改善功效的方法

ZL 202010256242.2

2020.04.02

6

用斑马鱼鳔损伤炎症模型评价肺损伤治疗剂与诱导剂的方法

ZL 201610956504.X

2016.11.03

7

一种用斑马鱼评价心肌损伤诱导剂毒性与治疗剂功效的方法

ZL 201610969159.3

2016.11.03

8

一种抗PM2.5咀嚼片及其制备方法

ZL 201610216744.6

2016.04.06

9

天然抗癫痫活性化合物及其在药物制剂中的用途(合作)

ZL 201410487432.X

2014.09.22

10

一种斑马鱼体内ROS检测模型的建立方法及其应用

ZL 201310398791.3

2013.09.05

11

一种斑马鱼类过敏检测模型的建立及其应用

ZL 201310262123.8

2013.06.27

12

建立斑马鱼肠蠕动模型及筛选促胃肠动力药物的方法

ZL 201310181252.4

2013.05.15

13

舒洛地尔在制备抗血管生成类药物中的应用

ZL 201310020569.X

2013.01.18

14

左旋沙丁胺醇在制备抗血管生成类药物中的应用

ZL 201310008036.X

2013.01.09

15

一种能抗血管生成的化合物及其用途

ZL 201210562409.3

2012.12.18

16

一种斑马鱼细菌感染模型的构建方法及其应用

ZL 201210377599.1

2012.09.27

17

斑马鱼多发性硬化症模型的建立方法及其应用

ZL 201210016072.6

2012.01.18

18

斑马鱼P-糖蛋白抑制剂筛选模型的建立方法及其应用

ZL 201110231726.2

2011.08.12

19

建立斑马鱼血栓模型的方法

ZL 201110126427.2

2011.05.17

20

在整体斑马鱼上进行酶联免疫吸附检测的方法及应用

ZL 201010547814.9

2010.11.17

21

一种利用斑马鱼筛选线粒体靶向化合物的方法

ZL 201010296696.9

2010.09.29

 

部分论文专著

序号

论文/文章专著(点击标题可查看详情)

作者

发表刊物

发表年份

1

Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish

Xiao-Yu Zhu, Bo Xia, Yu-Ying Wu, Hua Yang, Chun-Qi Li, Ping Li

AQUATIC TOXICOLOGY

2019

2

Sensitization and synergistic anticancer efects of Furanodiene identifed in zebrafsh models

Xiao-Yu Zhu, Dian-WuGuo, Qiao-Cong Lao, Yi-QiaoXu, Zhao-Ke Meng, BoXia, HuaYang, Chun-Qi Li & Ping Li

Scientific Reports

2019

3

A Zebrafish Heart Failure Model for Assessing Therapeutic Agents

Xiao-Yu Zhu, Si-Qi Wu, Sheng-Ya Guo, Hua Yang, Bo Xia, Ping Li, and Chun-Qi Li

ZEBRAFISH

2018

4

The Tilapia collagen peptide mixture TY001 protects against LPS-induced inflammation, disruption of glucose metabolism, and aberrant expression of circadian clock genes in mice

Xiao-Yun Xiong, Jun Liang, Yi-Qiao Xu & Yi Liu

CHRONOBIOLOGY INTERNATIONAL

2019

5

Development of zebrafish demyelination model for evaluation of remyelination compounds and RORγt inhibitors

Xiao-Yu Zhu, Sheng-Ya Guo, Bo Xia, Chun-Qi Li, Lei Wang, Yong-Hui Wang

Journal of Pharmacological and Toxicological Methods

2019

6

The wound healing effects of the Tilapia collagen peptide mixture TY001 in streptozotocin diabetic mice

Xiaoyun Xiong, Jun Liang, Yiqiao Xu, Jie Liu, Yi Liu

J Sci Food Agric

2020

7

Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish

Xiao-Yu Zhu, Yu-Ying Wu, Bo Xia, Ming-Zhu Dai, Yan-Feng Huang, Hua Yang, Chun-Qi Li, Ping Li

Neurotoxicology

2020

8

A natural complex product Yaocha reduces uric acid level in a live zebrafish model

Xiao-Yun Xiong, Jun Liang, Sheng-Ya Guo, Ming-Zhu Dai, Jia-Li Zhou, Yong Zhang, Yi Liu

Journal of Pharmacological and Toxicological Methods

2020

9

Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis

Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, and Xu-Wen Li

journal of natural products

2020

10

Ponatinib-induced ischemic stroke in larval zebrafish for drug screening

Xiao-Yu Zhu, Bo Xia, Ting Ye, Ming-Zhu Dai, Hua Yang, Chun-Qi Li, Ping Li

European Journal of Pharmacology

2020

11

Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish

Sheng-Ya Guo, Yong Zhang, Xiao-Yu Zhu, Jia-Li Zhou, Jiao Li, Chun-Qi Li, Li-Ren Wu

JOURNAL OF APPLIED TOXICOLOGY

2020

12

The protection of indolealkylamines from LPS-induced inflammation in zebrafish

Yu Zhang, Norio Takagi, Bo Yuan, Yanyan Zhou, Nan Si, Hongjie Wang, Jian Yang, Xiaolu Wei, Haiyu Zhao, Baolin Bian

Journal of Ethnopharmacology

2019

13

Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish

Zheng-Cai Du, Zhong-Shang Xia, Yan-Feng Huang, Yi Peng, Bing-Bing Cao, Chun-Qi Li, Yun-Fei Liang, Fang-Hui Zhao, Ming-Zhe Zhang, Zhang-Mei Chen, Xiao-Tao Hou, Er-Wei Hao, Jia-Gang Deng

JOURNAL OF APPLIED TOXICOLOGY

2020

14

Fangjihuangqi Decoction inhibits MDA-MB-231 cell invasion in vitro and decreases tumor growth and metastasis in triple-negative breast cancer xenografts tumor zebrafish model

Yubo Guo, Yingyi Fan, Xiaohua Pei

Cancer Medicine

2020

15

Sea Cucumber Intestinal Peptide Induces the Apoptosis of MCF-7 Cells by Inhibiting PI3K/AKT Pathway

Wei Wei, Xiao-Man Fan, Shao-Hui Jia, Xi-Ping Zhang, Zhao Zhang, Xue-Jun Zhang, Jiu-Xun Zhang and Ye-Wang Zhang

frontiers in nutrition

2021

16

Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal MultiScale Treatment Strategy for Septic Syndrome in COVID-19

Tengwen Liu, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Qingquan Liu, and Xiaolong Xu

frontiers in pharmacology

2020

17

Sanggenon C Stimulates Osteoblastic Proliferation and Differentiation, Inhibits Osteoclastic Resorption, and Ameliorates Prednisone-Induced Osteoporosis in Zebrafish Model

Huijuan Wang, Tingting Feng, Donggui Guo, Min Zhang, Lin Chen and Ying Zhou

molecules

2018

18

Lentinan Impairs the Early Development of Zebrafish Embryos, Possibly by Disrupting Glucose and Lipid Metabolism

Wenyu Miao, Lingling He, Tao Zhang and Chunqi Li

processes

2022

19

Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models

Meng Chen, Chinfeng Liu, Mingzhu Dai, Qinwen Wang, Chunqi Li, Weilian Hung

plos one

2022

20

Ferroptosis is partially responsible for dexamethasone-induced T cell ablation, but not osteoporosis in larval zebrafish

Wenyu Miao, Lingling He, Yong Zhang, Xiaoyu Zhu, Yangming Jiang, Pengpeng Liu, Tao Zhang, Chunqi Li

Ecotoxicology and Environmental Safety

2022