Preclinical researches based on the zebrafish models, such as active compound discovery, high-throughput drug screening, pharmacological evaluation, safety assessment, and biological quality control. Zebrafish experiments have advantages in duration and costs, as well as providing intuitive results, which will empower pharmaceutical companies in drug research and development, quality control, and promotional activities.
Pharmacological Evaluation and Drug Screening
Cancer Diseases
| Anti-tumor effect | Anti-angiogenic effect |
| Multidrug resistance reversal effect | Inductive effect on Caspase factors |
| Inhibitory effect on Wnt signaling pathway |
Cardiovascular and cerebrovascular diseases
| Pro-angiogenic effect | Hepatoprotective effect against bleeding |
| Pro-vascular regeneration effect | Anti-endothelial injury thrombotic effect |
| Antiplatelet aggregate thrombotic effect | Vasodilatory effect (anti-erythrocyte injury thrombotic effect) |
| Anti-stasis and blood stasis type thrombotic effect | Heart failure prevention |
| Myocardium protection | Cerebral thrombosis prevention |
| Cerebral hemorrhage prevention | Antioxidant effect |
Neurological Diseases
| Central nervous system (CNS) protective effect | Calming and sleep aid effect |
| Hearing protection effect | Antiepileptic effect |
| Anxiolytic effect | Preventive and therapeutic effect on Parkinson's disease (PD) |
| Preventive and therapeutic effect on Alzheimer's disease (AD) | Axonal regeneration effect |
Hematological Disease
| Improvement of anemia effect |
Hepatorenal diseases
| Protective effect against alcoholic liver damage | Hepatoprotective and hangover-relieving effect |
| Hepatoprotective effect | Renoprotective effect |
| Preventive and therapeutic effect against pneumonia | Effect on cytochrome P450 |
Inflammation and Immunity
| Modulation of T cells | Modulation of macrophages |
| Modulation of neutrophils | Protective and therapeutic effect on colitis |
| Anti mechanical inflammation effect | Anti neurogenic inflammation effect |
| Anti bacterial inflammation effect |
Metabolic Disorders
| Effect of improving thickening of blood vessel walls | Lipid-lowering effect |
| Neuroprotective effect in diabetes | Anti neural inflammation effect in diabetes |
| Screening for energy regulators | Screening for gastrointestinal motility inhibitors |
| Anti-PM2.5 effect | Blood sugar-lowering effect |
| Hangover-relief effect | Uric acid-lowering effect |
| Laxative effect |
Visual Functiones
| Visual Protective Effect | Preventive a Effects on Macular Degeneration |
Musculoskeletal Diseases
| Promotion of growth and development effect | Promotion of tissue regeneration/wound healing effect |
| Osteoporosis treatment agent | Cartilage repair effect |
| Analgesic effect |
Others
| Intestinal digestion function | Intestinal mucus secretion function |
| Effect of improving bradycardia | Effect of improving cardiac hemorrhage |
| Antidepressant effect | Gastric and intestinal mucosal injury |
| For more, please consult online |
Nonclinical Safety Evaluation - Toxicity Assessment
| Oxidative stress | Reproductive toxicity |
| Embryotoxicity | Acute toxicity |
| Median lethal dose (LD50) | Cardiovascular toxicity |
| Hepatotoxicity | Neurotoxicity |
| Nephrotoxicity | Osteotoxicity |
| Behavioral toxicity | Cell apoptosis |
| Developmental toxicity and teratogenic risk | Ototoxicity |
| Cutaneous and muscular toxicity | Immunotoxicity |
| Inflammatory response | Allergic reaction |
| Gastrointestinal toxicity | Hematotoxicity |
| Genotoxicity | Ocular toxicity |
| Carcinogenic risk |
